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KMID : 1123920090230051139
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 5 p.1139 ~ p.1144
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Studies of the Anti-cancer Effects of Bistortae Rhizoma
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Kim June-Beom
Han Hyo-Sang
Lee Young-Jong
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Abstract
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This study was purposed to research the anti-cancer effects of Bistortae Rhizoma. A total extract of Bistortae Rhizoma decoction was prepared. By measuring the cell proliferation, apoptosis, morphology and cytokine level from the extracts, the influence on HepG2 cell, SNU-1 cell and A549 cell was compared. The Bistortae Rhizoma decoction extract did not control HepG2 cell proliferation but controlled SNU-1 cell and A549 cell proliferation. In particular, the inhibitory effect on SNU-1 cell proliferation was highest. The Bistortae Rhizoma decoction extract showed to increase the apoptosis of the HepG2 cell, SNU-1 cell and A549 cell in a dose-dependent manner. In particular, the promotion effect of the apoptosis was highest in SNU-1 cell. Among the various fraction extracts of the Bistortae Rhizoma decoction, n-BuOH extraction showed the greatest increase of the apoptosis of the HepG2 cell. The Bistortae Rhizoma decoction extract decreased dose-dependently the secretion of the TGF-β in the HepG2 cell, SNU-1 cell and A549 cell and increased the secretion of the TNF-α and the IFN-γ. These results suggest that the total extract of Bistortae Rhizoma decoction has anti-cancer effect against SNU-1 cell and A549 cell.
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KEYWORD
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Bistortae Rhizoma, Bistorta manshuriensis Komarov, HepG2 cell, SNU-1 cell, A549 cell, anti-cancer effects
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